if anxiety is caused by high levels of serotonin, then why to SSRI's help?

if anxiety is caused by high levels of serotonin, then why to SSRI's help? Topic: if anxiety is caused by high levels of serotonin, then why to SSRI's help?
June 26, 2019 / By Zinnia
Question: im currently doing my psychology degree revision and im really stumped about a set of conflicting theories surrounding anxiety disorders. evidence for buspirone helping anxiety: has high affinity for 5-HT1A receptors &, via somatodendritic autoreceptors, acts to reduce 5-HT release in forebrain action is consistent with many research reports showing that anxiety is associated with increased 5-HT in brain ok so high 5-HT could be the cause of anxiety. if this is the case then why do SSRI's (reuptake inhibitors that increase the amount of 5-HT) help anxiety? surely if anything it would make it worse since there would be more serotonin? thanks @aneurodo... a quote from the papers abstract: There is evidence of serotonergic involvement in anxiety, in that serotonin agonists may increase anxiety, whilst drugs that reduce serotonin function are anxiolytic. so surely SSRI's act as serotonin agonists? - increasing anxiety?
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Best Answers: if anxiety is caused by high levels of serotonin, then why to SSRI's help?

Sherill Sherill | 4 days ago
I was wondering what causes this disorder in the1st place.I am thinking outside of the medical issues in the way of psychosomaticly we cause our own chemistry unbalance ourselves.There for we can reverse our our thinking and our physical differences for the better.I believe we can change ourselves 4 the better through our own programing. I know our minds & spirits can achieve this if we so choose to" flip it" reverse.The mind body & spirit is a powerful entity.I always believed this,I had done it.I don't take any meds 4 the title given me which was bipolar disorder & OCD,I had curb this so called disorder to almost 97%.It's no miracle,it's just the way I come to think & believe .I always said if you are not your labels then don't subcome to them.I don't have any degrees or actually philological in school training,other then my own personal experiences "walk the walk thing" and reading on it etc.etc..Dose anyone agree with me on any of this?I think it could help the asker in his study on this.
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Sherill Originally Answered: I believe I have SSRI sexual dysfunction can anyone help?
Treatment of antidepressant-induced sexual dysfunction can be hard to do, and medications or other type of treatments have not been studied extensively. However there are some medications that have a modest amount of anecdotal evidence and a little testing. How long ago did you stop taking all antidepressants? In some cases it may take months or even longer but the problem does TYPICALLY go away. If you still have anxiety problems I absolutely recommend you consider treatment and many medications like benzodiazepines are effective that do NOT cause sexual dysfunction. Serzone (nefazodone) is a type of antidepressant but it has different actions than a SSRI like citalopram. It may be helpful but the studies conducted have been of just a handful of people and they were not exactly high quality. This might be a good option if you still have anxiety problems. BuSpar (buspirone) is used to treat anxiety, typically generalized anxiety disorder (GAD). It has similar actions to antidepressants although it is not an antidepressant. The evidence with this drug is very low like it is with Serzone. But again if anxiety is still a problem BuSpar may be a good option. Wellbutrin (bupropion) is probably the most commonly used treatment and considered to be very effective by many doctors although, again, there is very little evidence it works well. However the evidence we do have is all very positive and there is a significant amount of anecdotal information. It is a very unique antidepressant that acts on dopamine where as other antidepressants act on norepinephrine and/or serotonin, what you took only acts on serotonin. The problem is that it may worsen anxiety in some people so if your anxiety is not well controlled this may make it worse, even if it is controlled the anxiety could get worse. Medications with the most evidence they work are stimulants, primarily Dexedrine (dextroamphetamine) and also Ritalin (methylphenidate). Typically only a low-modest dose is required whereas the other medications typically require the same type of dose needed to help the problem, often a dose on the high side of normal. The major problems with these drugs are that they may increase anxiety, like Wellbutrin, however since a lower dose may be helpful that may not be as much of an issue and these are controlled substances. In The United States both drugs are schedule II controlled substances so if you have a personal history of substance abuse or, to a smaller extent, a family history of substance abuse, then these medications are may not the best. All the drugs are available as a generic, Wellbutrin is by far the most expensive, followed by BuSpar, Serzone, Ritalin, and Dexedrine.

Pene Pene
OK- serotonin is released at the synapse. Once it has done it's thing, it is taken up by the nerve ending and re-cycled. An efficient way not to have to manufacture so much. SO if you block the re-uptake, more serotonin stays at the synapse and drives the receptor cell more. Very simplistic explanation-the long version is pretty complicated. Depression causes low energy.An SSRI should help. Serotonin is the "feel good " neurotansmitter.
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Marise Marise
Anxiety is associated with increased levels of norepinephrine and decreased activity of GABA and serotonin. SSRI's are thought to be effective due to their ability to increase levels of Serotonin. Buspirone has high affinity for 5-HT 1A receptors and it acts as a partial agonist at these sites. This means that buspirone can act to stabilize serotonin levels if they are abnormally low or abnormally high. In this way, buspirone works at the 5-HT1A receptor in a similar way as aripiprazole works at the D2 receptor.
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Kristie Kristie
Here is one reference. While both are involved, I think the adrenergic system dominates in anxiety. You will note that centrally acting adrenergic blockers not only suppress tremor, but actually decrease anxiety levels. http://www.ncbi.nlm.nih.gov/pubmed/19634...
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Kristie Originally Answered: What are your favorite sources for AGW information at the following levels?
1.Center for Climate and Energy Solutions - Kids Corner - it has answers to questions about global warming which children may ask. http://www.c2es.org/global-warming-basics/kidspage.cfm Global Warming Facts for Kids - it describes activities that cause global warming and actions that children can do. http://www.ehow.com/facts_4855492_global-warming-kids.html 2. Skeptical Science - it is a valuable resource for someone who wants to understand global warming and why over 170 "skeptic" arguments do not disprove global warming. http://www.skepticalscience.com/ Brave new climate - it is also a source of information about global warming and it counters misinformation about nuclear power. http://bravenewclimate.com/ 3. Realclimate - it has frequent articles about global warming. http://www.realclimate.org/ Science of Doom - it gets into the physics of global warming http://scienceofdoom.com/ Fringe experts should also keep abreast of what is on skeptic sites, such as wattsupwiththat, CO2science and Roy Spencers blog. Some information on these sites is actually useful, such as http://www.drroyspencer.com/2010/08/help-back-radiation-has-invaded-my-backyard/ and http://wattsupwiththat.com/2011/03/29/a-new-form-of-hydroelectric-power-no-dam-needed/ 4. Databases to peer reviewed literature.

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